Efficient detection of hydrogen bonds in dynamic regions of RNA by sensitivity-optimized NMR pulse sequences.

Andre Dallmann,Bernd Simon,Malgorzata M Duszczyk,Hamed Kooshapur,Arthur Pardi,Wolfgang Bermel,Michael Sattler

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION（2013）

引用 26|浏览5

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摘要

Improved Sensitivity: Efficient NMR experiments are presented for determining the secondary structure in large and dynamic RNAs using J-couplings across hydrogen bonds. The experiments provide up to eight-fold improved sensitivity and thus enable detection of base pairs in dynamic regions even in large RNAs.

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关键词

base pairs,hydrogen bonds,NMR spectroscopy,RNA dynamics,RNA secondary structure

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