Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.

Guangwen Shu,Xue Mi,Jian Cai,Xinlin Zhang,Wu Yin,Xinzhou Yang,You Li,Lvyi Chen,Xukun Deng

Toxicology Letters（2013）

引用 46|浏览22

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摘要

•Brucine represses HCC cell migration in vitro.•Brucine represses HCC metastasis in vivo.•Brucine exhibits low toxic effect at the dosage of 15mg/kg.•Brucine suppresses HIF-1 dependent transcription.

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关键词

ALT,AST,BUN,CRE,Ctsd,FACS,GAPDH,HCC,Hb,HIF-1,Lox,Mmp2,MS,MTT,NMR,OD,PCR,PHD,PLT,RBC,S. nux-blanda,S. nux-vomica,SPF,TASNB,TASNV,UA,WBC

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