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Response to dasatinib in a patient with SQCC of the lung harboring a discoid-receptor-2 and synchronous chronic myelogenous leukemia.

Vincenzo Pitini,Carmela Arrigo,Cristian Di Mirto,Patrizia Mondello,Giuseppe Altavilla

Lung Cancer（2013）

Cited 51|Views7
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Abstract
We report a patient with squamous cell carcinoma (SQCC) of the lung and a discoid-receptor-2 (DDR2) kinase domain mutation that responded to dasatinib treatment. Our case report is consistent with previous publications suggesting that DDR2 mutation may confer sensitivity to dasatinib.
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Key words
Squamous-cell carcinoma,Dasatinib,Chronic myelogenous leukemia,DDR2,Driver mutations,Targeted therapies
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