谷歌Chrome浏览器插件
订阅小程序
在清言上使用

Expression of steroidogenic factor 1 and pituitary specific transcription factor 1 in rat pituitary adenomas.

JOURNAL OF TOXICOLOGIC PATHOLOGY(2013)

引用 4|浏览4
暂无评分
摘要
The protein expressions of steroidogenic factor 1 (SF-1) and pituitary-specific transcription factor 1 (Pit-1) were investigated immunohistochemically for 53 spontaneous pituitary adenomas of the pars distalis from male Crl:CD(SD) rats. Luteinizing hormone (LH)-positive/prolactin (PRL)-negative and LH-negative/PRL-positive adenomas showed that the expression of SF-1 and Pit-1 was exclusively related to the immunoreactivity of LH and PRL, respectively. All double-positive adenomas (positive for both LH and PRL) were positive for Pit-1 and were supposed to be derived from PRL cells, although some of them also showed SF-1 immunoreactivity. In addition, all null cell adenomas (negative for all anterior pituitary hormones) were positive for SF-1 and negative for Pit-1, indicating that they originated from the gonadotroph cell lineage. This is the first report focusing on the application of transcription factors for the classification of rat pituitary adenomas.
更多
查看译文
关键词
pituitary adenoma,steroidogenic factor 1,pituitary-specific transcription factor 1,rat
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要