Regulator of G protein signaling 19 suppresses Ras-induced neoplastic transformation and tumorigenesis.
Cancer Letters（2013）
Abstract
•Ras is a potent oncogene found in many types of tumors.•RGS19 has been shown to inhibit Ras signaling via the up-regulation of Nm23.•Expression of RGS19 can suppress Ras-induced neoplastic transformation and tumor formation.•Knockdown of RGS19 enhances tumorigenesis in some cancer cells.
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Key words
ERK,GAIP,Nm23,Ras,RGS19
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