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Effect of human 15-lipoxygenase-1 metabolites on vascular function in mouse mesenteric arteries and hearts.

Tamas Kriska,Cody Cepura,Lawan Siangjong,Tina C Wan,John A Auchampach,Aviv Shaish,Dror Haratz,Ganesh Kumar,John R Falck,Kathryn M Gauthier,William B Campbell

Prostaglandins & Other Lipid Mediators（2013）

Cited 7|Views12
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Abstract
•Arachidonic acid metabolites of human 15-LO enzyme are vasoactive.•Preproendothelin-1 controlled human 15-LO transgene is highly expressed in heart.•Human 15-LO transgene enhances coronary flow following an ischemia.•15-LO metabolites contribute to coronary reactive hyperemia.
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LOs,AA,ACh,HPETEs,HETEs,HEETAs,THETAs,sEH,EDHFs,l-NA,Indo,NDGA
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