GSK3β/β-catenin signaling is correlated with the differentiation of glioma cells induced by wogonin.

Yajing Wang,Yi Zhang,Chen Qian,Min Cai,Yan Li,Zhiyu Li,Qidong You,Qing Wang,Rong Hu,Qinglong Guo

Toxicology Letters（2013）

引用 26|浏览9

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摘要

•Wogonin inhibited C6 cells growth and arrested at G0/G1 phase of the cell cycle.•Wogonin induced typical morphological changes and an increase in GFAP level.•Induction of cell differentiation by wogonin ascribed to the restrain of GSK-3β/β-catenin pathway.•Blocking GSK-3β/β-catenin signaling promotes the glial differentiation of glioma cells.

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关键词

Wogonin,Glioblastoma cells,Differentiation,GSK-3β/β-catenin pathway,Cell cycle

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