Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation

Barbora Orlikova,Marc Schumacher,Tom Juncker,Choo Chee Yan,Salmaan H. Inayat-Hussain,Shéhérazade Hajjouli,Claudia Cerella,Mario Dicato,Marc Diederich

Food and Chemical Toxicology（2013）

引用 35|浏览3

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摘要

•(R)-(+)-Goniothalamin (GTN) induces apoptosis in leukemia cells.•GTN shows no toxicity towards healthy cells.•GTN inhibits tumor necrosis factor-α (TNF-α)-induced NF-κB activation in leukemia cells.•GTN reduces the proteolytic activity of the proteasome.•GTN inhibits NF-κB activation at non-apoptogenic concentrations in human leukemia.

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关键词

BSA,EMSA,GTN,IKKβ,IL-8,NF-κB,NIK,PBMC,TAB1,TAK1,TNF-α,TNFR-1,TRADD,TRAF2

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