Direct tandem mass spectrometric profiling of sulfatides in dry urinary samples for screening of metachromatic leukodystrophy.
Clinica Chimica Acta（2013）
Abstract
•Easy transportation of urine samples dried on DEAE-cellulose membranes•Partial purification of sulfatides•Reliable monitoring of specific changes in the sulfatide isoforms in MLD patients•Use of the indigenous sulfatide isoform (with C18:0 fatty acid) as reference•Simplified analytical procedure and lower cost of analysis important for screening
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Key words
CV,DEAE,MLD,Psap-d,ASA,PTFE,SRM,MS/MS,S/N,IPN,DUS
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