High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.
Journal of Chromatography B（2013）
摘要
•Quantification of a gemcitabine prodrug, gemcitabine, and dFdU in single LC/MS/MS analysis.•Use of column-switching chromatography.•Using diverse assay ranges within a single LC–MS/MS analysis.
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关键词
Prodrug,Gemcitabine,Column switching,LC–MS/MS
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