A new metabolomic workflow for early detection of Alzheimer's disease.

Clara Ibáñez,Carolina Simó,Dinesh K Barupal,Oliver Fiehn,Miia Kivipelto,Angel Cedazo-Mínguez,Alejandro Cifuentes

Journal of Chromatography A（2013）

引用 83|浏览5

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摘要

•RP/UHPLC–MS and HILIC/UHPLC–MS methods developed for metabolic analysis of CSF samples.•Altered metabolic fingerprints were related to AD progression in CSF samples.•The accuracy of the prediction model from MCI to AD was 98.7%.•Specificity and sensitivity of the prediction model from MCI to AD were above 95%.

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关键词

Metabolomics,Alzheimer's disease,UHPLC–MS,Multivariate statistical analysis

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