Characteristics of HIV-2 and HIV-1/HIV-2 Dually Seropositive Adults in West Africa Presenting for Care and Antiretroviral Therapy: The IeDEA-West Africa HIV-2 Cohort Study.

Didier K Ekouevi,Eric Balestre,Patrick A Coffie,Daouda Minta,Eugene Messou,Adrien Sawadogo,Albert Minga,Papa Salif Sow,Emmanuel Bissagnene,Serge P Eholie,Geoffrey S Gottlieb,François Dabis,Djimon Marcel Zannou,Carin Ahouada,Jocelyn Akakpo, Christelle Ahomadegbé,Jules Bashi,Alice Gougounon-Houéto,Angèle Azon-Kouanou,Fabien Houngbé,Sikiratou Koumakpaï, Florence Alihonou, Marcelline d'Almeida,Irvine Hodonou, Ghislaine Hounhoui,Gracien Sagbo,Leïla Tossa-Bagnan,Herman Adjide,Joseph Drabo,René Bognounou,Arnaud Dienderé,Eliezer Traore, Lassane Zoungrana,Béatrice Zerbo,Adrien Bruno Sawadogo,Jacques Zoungrana,Arsène Héma,Ibrahim Soré,Guillaume Bado, Achille Tapsoba,Diarra Yé,Fla Kouéta,Sylvie Ouedraogo,Rasmata Ouédraogo,William Hiembo,Mady Gansonré,Eugène Messou,Joachim Charles Gnokoro,Mamadou Koné,Guillaume Martial Kouakou,Clarisse Amani Bosse, Kouakou Brou,Achi Isidore Assi,Henri Chenal,Denise Hawerlander,Franck Soppi,Albert Minga,Yao Abo,Germain Bomisso,Serge Paul Eholié,Mensah Deborah Noelly Amego,Viviane Andavi,Zelica Diallo,Frédéric Ello, Aristophane Koffi Tanon,Serge Olivier Koule, Koffi Charles Anzan,Calixte Guehi,Edmond Addi Aka,Koffi Ladji Issouf,Jean-Claude Kouakou,Marie-Sylvie N'gbeche,Pety Touré, Divine Avit-Edi,Kouadio Kouakou,Magloire Moh,Valérie Andoblé Yao,Madeleine Amorissani Folquet, Marie-Evelyne Dainguy,Cyrille Kouakou,Véronique Tanoh Méa-Assande,Gladys Oka-Berete,Nathalie Zobo,Patrick Acquah,Marie-Berthe Kokora,Tanoh François Eboua,Marguerite Timité-Konan,Lucrèce Diecket Ahoussou,Julie Kebé Assouan, Mabéa Flora Sami,Clémence Kouadio,Lorna Renner, Bamenla Goka, Jennifer Welbeck,Adziri Sackey,Seth Ntiri Owiafe,Christian Wejse,Zacarias José Da Silva, Joao Paulo,Amabelia Rodrigues,David da Silva,Candida Medina,Ines Oliviera-Souto,Lars Ostergaard,Alex Laursen,Morten Sodemann,Peter Aaby,Anders Fomsgaard,Christian Erikstrup,Jesper Eugen-Olsen,Moussa Y Maïga, Fatoumata Fofana Diakité,Abdoulaye Kalle, Drissa Katile,Hamar Alassane Traore,Daouda Minta,Tidiani Cissé, Mamadou Dembelé,Mohammed Doumbia,Mahamadou Fomba, Assétou Soukho Kaya, Abdoulaye M Traoré, Hamady Traoré,Amadou Abathina Toure,Fatoumata Dicko,Mariam Sylla, Alima Berthé, Hadizatou Coulibaly Traoré,Anta Koïta, Niaboula Koné, Clémentine N'diaye,Safiatou Touré Coulibaly,Mamadou Traoré,Naïchata Traoré,Man Charurat,Samuel Ajayi,Stephen Dapiap, Otu,Festus Igbinoba,Okwara Benson,Clément Adebamowo, Jesse James, Obaseki,Philip Osakede, John Olasode,Papa Salif Sow, Bernard Diop,Noël Magloire Manga,Judicael Malick Tine,Haby Signate Sy,Abou Ba,Aida Diagne,Hélène Dior,Malick Faye, Ramatoulaye Diagne Gueye, Aminata Diack Mbaye, Akessiwe Patassi,Awèrou Kotosso,Benjamin Goilibe Kariyare,Gafarou Gbadamassi,Agbo Komi,Kankoé Edem Mensah-Zukong,Pinuwe Pakpame, Annette Koko Lawson-Evi, Yawo Atakouma,Elom Takassi, Améyo Djeha,Ayoko Ephoévi-Gah,Sherifa El-Hadj Djibril,François Dabis,Emmanuel Bissagnene,Elise Arrivé,Patrick Coffie,Didier Ekouevi,Antoine Jaquet,Valériane Leroy,Charlotte Lewden,Annie Sasco, Jean-Claude Azani,Gérard Allou,Eric Balestre,Franck Bohossou,Sophie Karcher,Jules Mahan Gonsan,Jérôme Le Carrou,Séverin Lenaud,Célestin Nchot,Karen Malateste,Amon Roseamonde Yao, Bertine Siloué, Gwenaelle Clouet,Hugues Djetouan,Alexandra Doring,Adrienne Kouakou,Elodie Rabourdin, Jean Rivenc,Xavier Anglaret,Boubacar Ba, Jean Bosco Essanin,Andrea Ciaranello,Sébastien Datté,Sophie Desmonde,Jean-Serge Elvis Diby,Geoffrey S Gottlieb, Apollinaire Gninlgninrin Horo, Serge N'zoré Kangah,Denis Malvy,David Meless,Aida Mounkaila-Harouna,Camille Ndondoki,Caroline Shiboski, Rodolphe Thiébaut, Pac-Ci, Abidjan

PloS one（2013）

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摘要

BACKGROUND:HIV-2 is endemic in West Africa. There is a lack of evidence-based guidelines on the diagnosis, management and antiretroviral therapy (ART) for HIV-2 or HIV-1/HIV-2 dual infections. Because of these issues, we designed a West African collaborative cohort for HIV-2 infection within the framework of the International epidemiological Databases to Evaluate AIDS (IeDEA). METHODS:We collected data on all HIV-2 and HIV-1/HIV-2 dually seropositive patients (both ARV-naive and starting ART) and followed-up in clinical centres in the IeDEA-WA network including a total of 13 clinics in five countries: Benin, Burkina-Faso Côte d'Ivoire, Mali, and Senegal, in the West Africa region. RESULTS:Data was merged for 1,754 patients (56% female), including 1,021 HIV-2 infected patients (551 on ART) and 733 dually seropositive for both HIV-1 and HIV 2 (463 on ART). At ART initiation, the median age of HIV-2 patients was 45.3 years, IQR: (38.3-51.7) and 42.4 years, IQR (37.0-47.3) for dually seropositive patients (p = 0.048). Overall, 16.7% of HIV-2 patients on ART had an advanced clinical stage (WHO IV or CDC-C). The median CD4 count at the ART initiation is 166 cells/mm(3), IQR (83-247) among HIV-2 infected patients and 146 cells/mm(3), IQR (55-249) among dually seropositive patients. Overall, in ART-treated patients, the CD4 count increased 126 cells/mm(3) after 24 months on ART for HIV-2 patients and 169 cells/mm(3) for dually seropositive patients. Of 551 HIV-2 patients on ART, 5.8% died and 10.2% were lost to follow-up during the median time on ART of 2.4 years, IQR (0.7-4.3). CONCLUSIONS:This large multi-country study of HIV-2 and HIV-1/HIV-2 dual infection in West Africa suggests that routine clinical care is less than optimal and that management and treatment of HIV-2 could be further informed by ongoing studies and randomized clinical trials in this population.

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antiretroviral therapy,west africa presenting,cohort study,iedea-west

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