A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor.

Kevin R W Ngoei,Bruno Catimel,Nadia Milech,Paul M Watt,Marie A Bogoyevitch

The International Journal of Biochemistry & Cell Biology（2013）

Cited 8|Views6

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Abstract

•A d-amino acid peptide D-PYC98 is a 5-fold more potent JNK inhibitor than L-PYC98.•D-PYC98 is a pan JNK inhibitor that shows substrate preference.•The related stress-activated p38α MAPK, but not ERK2 MAPK, is inhibited by D-PYC98.•Biophysical interaction studies show direct D-PYC98-JNK1 interaction.•TAT-conjugated D-PYC98 inhibits JNK activity in cells.

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Key words

c-Jun N-terminal kinase,Peptide inhibitor,Activity assays,Binding assays,Substrate selectivity

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