A novel retro-inverso peptide is a preferential JNK substrate-competitive inhibitor.
The International Journal of Biochemistry & Cell Biology(2013)
Abstract
•A d-amino acid peptide D-PYC98 is a 5-fold more potent JNK inhibitor than L-PYC98.•D-PYC98 is a pan JNK inhibitor that shows substrate preference.•The related stress-activated p38α MAPK, but not ERK2 MAPK, is inhibited by D-PYC98.•Biophysical interaction studies show direct D-PYC98-JNK1 interaction.•TAT-conjugated D-PYC98 inhibits JNK activity in cells.
MoreTranslated text
Key words
c-Jun N-terminal kinase,Peptide inhibitor,Activity assays,Binding assays,Substrate selectivity
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined