Neuraminidase inhibitor susceptibility profile of pandemic and seasonal influenza viruses during the 2009-2010 and 2010-2011 influenza seasons in Japan.

Clyde Dapat,Hiroki Kondo,Isolde C Dapat,Tatiana Baranovich,Yasushi Suzuki,Yugo Shobugawa,Kousuke Saito,Reiko Saito,Hiroshi Suzuki

Antiviral Research（2013）

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摘要

•Susceptibility of influenza viruses to all four NAIs was determined by IC50 method.•Prevalence of oseltamivir-resistant A(H1N1)pdm09 viruses increased to 3%.•A novel I222T mutation in NA showed a reduction in susceptibility to all four NAIs.•No NAI resistance was found among influenza A(H3N2) and B viruses in this study.

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关键词

Influenza,Half maximal inhibitory concentration (IC50),Oseltamivir,Zanamivir,Peramivir,Laninamivir

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