Repair of the (6-4) photoproduct by DNA photolyase requires two photons.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2013)
摘要
It takes two (photons) to tango: Single-turnover flash experiments showed that the flavoenzyme (6-4) photolyase uses a successive two-photon mechanism to repair the UV-induced T(6-4)T lesion in DNA (see picture). The intermediate (X) formed by the first photoreaction is likely to be the oxetane-bridged dimer T(ox)T. The enzyme could stabilize the normally short-lived T(ox)T, allowing repair to be completed by the second photoreaction.
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关键词
(6-4) photoproducts,DNA damage,DNA repair,enzyme catalysis,photolyases
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