Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids(2013)
Abstract
We have synthesized 16,22-diketocholesterol, a novel ligand for oxysterol-binding protein Osh4, and determined X-ray structure of the diketocholesterol in complex with Osh4. The X-ray structure shows that α7 helix of Osh4 assumes open conformation while the rest of Osh4, closed conformation, implying this diketocholesterol–bound Osh4 structure may represent a structural intermediate between the two conformations.
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Key words
Oxystrerols,Oxysterol-binding proteins,Osh4
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