Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4.
Journal of Neuroimmunology(2013)
Abstract
Neuromyelitis optica is a demyelinating disease characterized by a disease-specific autoantibody designated as NMO-IgG that specifically recognizes aquaporin-4, and the binding of NMO-IgG to AQP4 causes the progress of the disease. Prevention of the binding of NMO-IgG, therefore, may alleviate the disease. Here we have developed monoclonal antibodies against AQP4 with a baculovirus display system in order to obtain high affinity monoclonal antibodies against the extracellular domains of AQP4. Our monoclonal antibodies can block the binding of NMO-IgG in spite of their heterogeneity. Taken together, we propose that our monoclonal antibodies can be applied in clinical therapy for NMO patients.
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Key words
Aquaporin-4,NMO-IgG,Nueromyelitis optica,Monoclonal antibody
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