Immunogenicity and safety of the vaccinia virus LC16m8Δ vector expressing SIV Gag under a strong or moderate promoter in a recombinant BCG prime-recombinant vaccinia virus boost protocol.

Hirotaka Sato,Chen Jing,Mao Isshiki,Kazuhiro Matsuo,Minoru Kidokoro,Shiki Takamura,Xianfeng Zhang,Takashi Ohashi,Hisatoshi Shida

Vaccine（2013）

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摘要

•Replicating VV LC16m8Δ harboring high expression promoter elicited CTL more efficiently.•It was less virulent than m8Δ harboring the moderate promoter.•Gag expression increased the neurotoxicity of the vaccinia vector.•BCG prime/m8Δ boost regimen elicited long-lasting Gag specific effector memory T cells.

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关键词

HIV,SIV,Recombinant BCG,Recombinant vaccinia,CTL

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