Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

Stefanie Marzian,Phillip J Stansfeld,Markus Rapedius,Susanne Rinné,Ehsan Nematian-Ardestani,Jennifer L Abbruzzese,Klaus Steinmeyer,Mark S P Sansom,Michael C Sanguinetti,Thomas Baukrowitz,Niels Decher

NATURE CHEMICAL BIOLOGY（2013）

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摘要

Kv1 channel inhibitor and potential therapeutic lead achieves selectivity by binding both the conserved central cavity and newly identified side pockets, which provide the key determinants for channel specificity.

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nature chemical biology, science

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