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Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells.

Lucile Mollet,Pauline Robinet,Martine Dubois,Axel Aurouet,Thierry Normand,Stéphane Charpentier,Adelin Sureau,Camille Grandclement,Francine Garnache-Ottou, Eric Deconinck,Fabienne Brulé,Pierre Simon Rohrlich,Alain Legrand

Molecular Immunology（2013）

Cited 7|Views9
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Abstract
•GALIG is a cell death-related gene nested within the human galectin-3 locus.•GALIG pro-apoptotic function is counteracted by the anti-apoptotic Mcl-1.•During spontaneous neutrophil apoptosis, GALIG mRNAs are up-regulated.•In Acute Myeloid Leukemia cell samples, GALIG mRNAs are highly down-regulated.
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Key words
GALIG,Apoptosis,MCL-1,Neutrophils,Acute Myeloid Leukemia,Bone marrow
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