Substantia Nigra Hyperechogenicity As A Marker For Parkinson'S Disease: A Population-Based Study
NEURODEGENERATIVE DISEASES(2013)
摘要
Background: The clinical diagnosis of Parkinson's disease (PD) is currently anchored in its cardinal motor symptoms. According to hospital-based studies, an enlarged echogenicity in the area of the substantia nigra (SN) assessed with transcranial sonography (TCS) may represent a useful biomarker in the diagnosis of PD. Objective:To evaluate SN hyperechogenicity as a marker for PD in the Bruneck Study cohort, which is representative of the general elderly community. Methods: The diagnostic accuracy of TCS in distinguishing clinically diagnosed PD from nonparkinsonian subjects was assessed in 574 subjects from this cohort. Results: There was a good diagnostic accuracy of TCS in distinguishing PD subjects from nonparkinsonian subjects with an area under the curve value of 0.82. At a receiveroperating characteristic cut:ye analysis-based cutoff value for SN hyperechogenicity of 0.18 cm2, TCS had a sensitivity of 88.2% (95% confidence interval, Cl, 64.4-98.0), a specificity of 77.0% (95% Cl 72.8-80.6), a positive predictive value of 12.7% (95% Cl 7.8-20.0) and a negative predictive value of 99.4% (95% Cl 97.8-100.0) for subjects with clinically definite PD at baseline. When analyzing the same population after 5 years with regard to the presence of known and newly diagnosed PD cases, baseline TCS yielded very similar diagnostic accuracy values. Conclusion: SN hyperechogenicity may represent a useful bionnarker for PD not only in a hospital-based setting but also in the general community. Copyright (C) 2013 S.Karger AG, Basel
更多查看译文
关键词
Substantia nigra hyperechogenicity,Bionnarker,Neuroinnaging,General community,Parkinson's disease,Diagnostic accuracy
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要