Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons.

Rajesh Kumar,Ruth Nyakundi,Thomas Kariuki,Hastings Ozwara,Onkoba Nyamongo,Godfree Mlambo,Barry Ellefsen,Drew Hannaman,Nirbhay Kumar

Vaccine（2013）

引用 26|浏览4

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摘要

•We evaluated DNA vaccine encoding Pfs25, a malaria vaccine candidate antigen.•DNA delivery by in vivo electroporation in baboons elicited functional antibodies.•DNA prime and protein boost further enhanced blocking antibody response.•We also validated Pfs25TrPb-murine model for future evaluation of antibodies.

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关键词

Pfs25,Malaria,Transmission blocking vaccine,DNA vaccine,Electroporation,Prime boost

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