Small ubiquitin-like modifier-4 Met55Val polymorphism is associated with glycemic control of Type 2 diabetes mellitus in Taiwan

Aim : Thedevelopment of Type2 diabetes mellitus (T2DM) has been recognized to beassociated with a combination of pancreatic β-cell dysfunction and insulin resistance. Nuclear factor-κB (NF-κB) has been recognized as one central mediator in the reaction of inflammation and proapoptotic event in β-cells. A functional polymorphism at the codon 55 (methionine to valine; A163G) of the small ubiquitin-like modifier-4 (SUMO4) gene may result in higher NF-κB activity. This study investigates whether this SUMO4 Met55Val polymorphism also contributes to the development of T2DM. Materials and methods : The study was peformed using genomic DNA samples from 574 Type 2 diabetic patients and 323 healthy controls. The SUMO4 Met55Val polymorphism was genotyped using allele-specific real-time PCR. Results : The frequency of the G allele (encoding Val55) was-significantly higher in Type 2 diabetic patients and Type 2 diabetic patients with the GG genotype had higherhemoglobin A 1c level. Multivariate logistic regression analysis revealed the genotype of GG and GA was an independent risk factor contributing to the development of T2DM. Conclusion : This study suggests that in Taiwan the SUMO4 Met 55Val polymorphism is associated with susceptibility to T2DM and Type 2 diabetic patients with GG genotype have worse glycemic control