Prognostic value of human papillomavirus types 16 and 18 DNA physical status in cervical intraepithelial neoplasia.
Clinical Microbiology and Infection(2013)
摘要
The aim of this work was to assess the value of the physical status of human papillomavirus (HPV) DNA as a disease marker for cervical cancer development in a set of 248 DNA samples previously genotyped as HPV 16 or 18, by calculating the E2/E6 ratio through real-time PCR. There was a significant difference in integration status according to disease grade for both genotypes (p <0.001). Furthermore, especially for HPV 18, determining the DNA physical status could be a useful biomarker in predicting cervical cancer risk development, with a lower E2/E6 ratio clinically associated with the development of a precancerous lesion.
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关键词
Cervical cancer,human papillomavirus 18,molecular marker,physical status,risk assessment
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