Controlled delivery of naltrexone by an intraoral device: in vivo study on human subjects.

Carlo Paderni,Giuseppina Campisi,Axel Schumacher,Thorsten Göttsche,Libero Italo Giannola,Viviana De Caro,Andy Wolff

International Journal of Pharmaceutics（2013）

Cited 17|Views5

No score

Abstract

Naltrexone is widely used in the treatment of opiate addiction but its current peroral administration is characterized by low bioavailability with various side effects. The development of a long-acting transbuccal delivery device (IntelliDrug) for NLX may be useful to improve patient compliance and the therapy effectiveness.

Translated text

Key words

NLX,HCL,GI,IV,AUC,LC–MS,MS,HPLC,SSRIs

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined