Paraoxonase1 (PON1) reduces insulin resistance in mice fed a high-fat diet, and promotes GLUT4 overexpression in myocytes, via the IRS-1/Akt pathway.

•PON1 Effect on insulin resistance was studied in mice fed high-fat-diet.•PON1 attenuates diabetes with a direct effect on glucose metabolism in muscles.•PON1 enhances GLUT4 expression, glucose uptake and cellular glycogen content in muscle.•PON1 anti-diabetic activity involve IRS-1/Akt pathway in the insulin signaling.