Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

Olivo Miotto,Jacob Almagro-Garcia,Magnus Manske,Bronwyn MacInnis,Susana Campino,Kirk A Rockett,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M Anderson,Socheat Duong,Chea Nguon,Char Meng Chuor,David Saunders,Youry Se,Chantap Lon,Mark M Fukuda,Lucas Amenga-Etego,Abraham V O Hodgson,Victor Asoala,Mallika Imwong,Shannon Takala-Harrison,François Nosten,Xin-zhuan Su,Pascal Ringwald,Frédéric Ariey,Christiane Dolecek,Tran Tinh Hien,Maciej F Boni,Cao Quang Thai,Alfred Amambua-Ngwa,David J Conway,Abdoulaye A Djimdé,Ogobara K Doumbo,Issaka Zongo,Jean-Bosco Ouedraogo,Daniel Alcock,Eleanor Drury,Sarah Auburn,Oliver Koch,Mandy Sanders,Christina Hubbart,Gareth Maslen,Valentin Ruano-Rubio,Dushyanth Jyothi,Alistair Miles,John O'Brien,Chris Gamble,Samuel O Oyola,Julian C Rayner,Chris I Newbold,Matthew Berriman,Chris C A Spencer,Gilean McVean,Nicholas P Day,Nicholas J White,Delia Bethell,Arjen M Dondorp,Christopher V Plowe,Rick M Fairhurst,Dominic P Kwiatkowski

NATURE GENETICS（2013）

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摘要

Dominic Kwiatkowski and colleagues report analysis of genetic variation in 826 Plasmodium falciparum samples collected from 10 locations in West Africa and southeast Asia. They characterize the population structure of this parasite in Cambodia and find evidence for multiple distinct subpopulations showing high levels of genetic differentiation and artemisinin resistance.

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关键词

Genomics,Malaria,Population genetics,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

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