Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts.

•Epileptic seizures in the mice neocortex were induced in vivo by intracortical injection of 4-aminopyridine.•Optical coherence tomography and photoacoustic images of the cortex were acquired simultaneously.•We have observed a decrease in optical scattering caused by the epileptic seizures.•We have observed vasodilatation of the small blood caused by the epileptic seizures.