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Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor

Ales Belic,Katalin Tóth,Radim Vrzal,Manna Temesvári,Pálma Porrogi,Erika Orbán,Damjana Rozman,Zdenek Dvorak,Katalin Monostory

Chemico-Biological Interactions（2013）

Cited 4|Views10
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Abstract
•DHEA decreases CYP1A induction by 3-methylcholanthrene in primary human hepatocytes.•DHEA reduces CYP1A2 mRNA levels, but does not influence CYP1A1 and CYP1B1 expression.•DHEA post-transcriptionally modifies CYP1A2 induction.•Androgen receptor is involved in the increased degradation of CYP1A2 mRNA.•It accounts for the protection against chemically induced carcinogenesis by DHEA.
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Key words
AhR,AhRR,ARNT,CYP,DHEA,MC,PAH
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