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Behavioral Effects of SQSTM1/p62 Overexpression in Mice: Support for a Mitochondrial Role in Depression and Anxiety

M. L. Seibenhener,Y. Du, L. Calderilla-Barbosa,J. Yan,M. C. Wooten

Behavioural Brain Research（2013）

Cited 15|Views6
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Abstract
•p62 overexpression increases the functionality of mitochondria in the hippocampus.•p62 overexpression changes behavior patterns related to affective spectrum disorders.•p62 overexpression effects on spatial learning and memory tasks in mice.
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Key words
Mitochondria,SQSTM1/p62,Animal model,Affective spectrum disorder,Depression,Anxiety
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