Preparation and characterization of "dextran-magnetic layered double hydroxide-fluorouracil" targeted liposomes.

The structure model of “dextran-magnetic layered double hydroxide-fluorouracil” liposomes (DMFL) is shown in this figure. The results of XRD, IR and TEM indicated that the hydrophilic group and lipophilic group in the phospholipid bilayer of liposomes, and the core skeleton DMF coexist in the DMFL. The magnetic skeleton DMF in the core of DMFL would enable this drug delivery system to display magnetic targeting; and the diphasic action between the DMF in liposomes and the inhibition of phospholipid bilayer together with the inherent controlled-release function of DMF should significantly strengthen slow-release performance of the DMFL.