Gold amides as anticancer drugs: synthesis and activity studies.

ORGANIC & BIOMOLECULAR CHEMISTRY(2013)

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摘要
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.
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gold amides,anticancer drugs
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