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Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity.

Nathaniel G dela Paz,Benoît Melchior,John A Frangos

Biochemical and Biophysical Research Communications（2013）

Cited 14|Views4
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Abstract
•Shear stress induces rapid phosphorylation of VEGFR2 Y1175 and Y1214 in human EC.•Early flow-induced VEGFR2 activation is VEGF-dependent.•MMP activity is involved in VEGF-dependent VEGFR2 activation in response to flow.
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Key words
Shear stress,VEGF,VEGFR2,Matrix metalloproteinase
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