Release of an ~55kDa fragment containing the actin-binding domain of β-spectrin by caspase-8 during FND-induced apoptosis depends on the presence of protein 4.1.

Monika Toporkiewicz,Michał Grzybek,Justyna Meissner,Izabela Michalczyk,Patrycja M Dubielecka,Justyna Korycka,Ewa Seweryn,Aleksander F Sikorski

Archives of Biochemistry and Biophysics（2013）

引用 9|浏览10

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摘要

•Apoptotic proteolysis of the β-spectrin releases the actin-binding domain.•Caspase-8 is responsible for this cleavage in cells.•This proteolysis depends on the presence of accessory protein(s) such as protein 4.1.

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关键词

Actin-binding domain,Apoptosis,Spectrin,Caspase-8,MS/MS analysis,Protein 4.1

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