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SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.

Srinivasa Karra,Yufang Xiao,Xiaoling Chen,Lesley Liu-Bujalski,Bayard Huck,Amanda Sutton,Andreas Goutopoulos,Ben Askew,Kristopher Josephson,Xuliang Jiang,Adam Shutes,Vikram Shankar,Tom Noonan,Gaianne Garcia-Berrios,Rong Dong,Mohanraj Dhanabal,Hui Tian,Zhenxiong Wang,A Clark,Samantha Goodstal

Bioorganic & Medicinal Chemistry Letters（2013）

Cited 14|Views14
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Abstract
The structure-based design, synthesis, and SAR of a novel series of Aurora kinase inhibitors based on the 5H-benzo[c][1,8]naphthyridin-6-one scaffold 1 are described.
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Key words
Aurora kinase inhibitors,Cancer,Aurora kinase A,Aurora kinase B,Benzonapthyridinones,DFG-out confirmation,Endoreduplication,phosphorylation of histone H3
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