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Synthesis, self-assembling and gene delivery potential of a novel highly unsaturated, conjugated cationic phospholipid

Christer L. Øpstad,Hans-Richard Sliwka,Vassilia Partali,Arnljot Elgsaeter,Philip Leopold,Emile Jubeli,Nada Abdul Khalique,Liji Raju,Michael D. Pungente

Chemistry and Physics of Lipids（2013）

Cited 7|Views10
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Abstract
•A new highly unsaturated cationic phospholipid is synthesized.•Its aggregation behavior, aggregate size and morphology are determined.•The lipid aggregate (liposome) forms with pDNA lipoplexes.•The lipoplexe formulated with DOPE and protamine shows in vitro transfection comparable to the standard reference Lipofectamine 2000.
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Key words
Carotenoids,Unsaturated cationic phospholipid,Self-assembling,Gene transfer
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