Activation of Nrf2-ARE signal pathway in hippocampus of amygdala kindling rats.
Neuroscience Letters(2013)
摘要
•Oxidative stress was induced in hippocampus of amygdala kindling rats.•Nrf2 and Nrf2-dependent gene products were significantly increased after seizure.•Nrf2-dependent gene products can protect the cells against oxidative damage.•To activate Nrf2-ARE signal pathway may be a new direction for treatment of epilepsy.
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关键词
Nrf2-ARE,Heme oxygenase-1,NAD(P)H:quinone oxidoreductase-1,Epilepsy,Oxidative stress
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