Unwinding the Wnt action of casein kinase 1

CELL RESEARCH（2013）

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摘要

The casein kinase 1 (CK1) family, a major intracellular serine/threonine kinase, is implicated in multiple pathways; however, understanding its regulation has proven challenging. A recent study published in Science identifying allosteric activation of CK1 by the DEAD-box RNA helicase DDX3 expands our understanding of the control of this abundant kinase family.

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关键词

CR, cancer, immunology, neurodegeneration, apoptosis, cell death, cell growth, differentiation

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