Interleukin-27 inhibits phagosomal acidification by blocking vacuolar ATPases.

Cytokine(2013)

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摘要
•The anti-inflammatory nature of IL-27 includes interference with lysosomes.•IL-27 inhibits phagosomal acidification.•IL-27 decreases the expression of vacuolar ATPase (V-ATPase).•IL-27 influence on lysosomal acidification compromises control of bacterial growth.
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关键词
IL-27,Latex beads,Phagosome,Phagolysosome,V-ATPase
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