Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors.
PEDIATRIC BLOOD & CANCER(2010)
Abstract
Introduction. High birth weight (HBW) is an established risk factor for childhood acute lympholblastic leukemia (ALL). The purpose of this Study was to evaluate if birth weight (BW) corrected-for-gestational age is a better predictor than BW alone for Occurrence of ALL and other malignancies in children. Materials and Methods. Birth certificate data of 2,254 children with cancer who were Younger than 5 years old at diagnosis and registered at Texas Cancer Registry during 1995-2003 were compared to 11,734 age-matched controls. Multivariable logistic regression Was used to compare models with BW corrected-for-gestational age and BW alone. Results. Compared to children who were appropriate for gestational age (AGA), children who were large for gestational age (LGA) at birth had a 1.66 times (959% CI 1.32-2.10) higher odds of ALL. Similarly, children with a BW >= 4,000 g had a 1.5 times (95% CI 1.18-1.89) higher odds for ALL, compared to children who weighed >2,500 and <4,000 g at birth. Using model diagnostics, the model containing BW corrected-for-gestational age was a better predictor than the model with BW alone [Akaike's Information Criterion (AIC) 4,646 vs. 4,658, respectively]. Odds ratios (OR) were similar for LGA children who were <4,000 g and LGA children who were >= 4,000 g (OR = 1.5, 95% CI 0.97-2.5 and OR = 1.67, 95% CI 1.29-2.16, respectively). BW was not an independent risk factor for acute myeloid leukemia or brain tumors. Conclusion. BW corrected-for-gestational age is a better predictor than BW alone of risk for ALL. Future Studies using BW variable Should incorporate gestational age in their analyses. Pediatr Blood Cancer 2010;54:242-249. (C) 2009 Wiley-Liss, Inc.
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Key words
birth weight,childhood acute lymphoblastic leukemia,gestational age
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