CCK-8S increased the filopodia and spines density in cultured hippocampal neurons of APP/PS1 and wild-type mice.

Lu-Lu Zhang,Xiao-Fei Wei,Yang-Hui Zhang,Shu-Jun Xu,Xiao-Wei Chen,Chuang Wang,Qin-Wen Wang

Neuroscience Letters（2013）

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摘要

•CCK-8S increased the density of filopodia and spines in wild type neurons.•CCK-8S increased the density of filopodia and spines in APP/PS1 neurons.•CCK-8S could promote the spine genesis both in neuron's early and mature stage.•CI988 could block the effect of CCK-8S on spine genesis.

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关键词

Cholecystokinin,Alzheimer's disease,Filopodium,Spine,Hippocampus

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