胃肠间质瘤辅助治疗新观点

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery(2013)

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Abstract
胃肠间质瘤(gastrointestinal stromal tumor,GIST)是最常见的胃肠道间叶源性肿瘤.经过近十余年的发展,GIST的治疗形成了以外科手术联合靶向药物的治疗模式.伊马替尼(imatinib mesylate,IM)作为GIST患者术后辅助治疗的一线药物,其应用显著减少了GIST患者的术后复发转移,延长了患者生存.对大多数高危风险GIST患者来说,目前SSGXVⅢ/AIO研究推荐伊马替尼术后辅助治疗至少应用3年.然而最佳的辅助治疗持续时间和随访方案尚未明确,仍处于边治疗边总结中,也期待能提出一指导个体化治疗的评估标准.
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Key words
Gastrointestinal stromal tumors,Adjuvant therapy,Imatinib mesylate,Life cycle
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