Influence of MDR1 C1236T polymorphism on lopinavir plasma concentration and virological response in HIV-1-infected children.

Carolina P Bellusci,Carlos Rocco,Paula Aulicino,Debora Mecikovsky,Verónica Curras,Soledad Hegoburu,Guillermo F Bramuglia,Rosa Bologna,Luisa Sen,Andrea Mangano

Gene（2013）

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摘要

•A pharmacogenetic study was performed in 38 HIV-1-infected children.•Children MDR1 1236CT showed lower LPV Cpost-dose than children MDR1 1236TT.•Children MDR1 1236CT had a lower decrease in plasma VL than children MDR1 1236CC.•The MDR1 C1236T SNP affects LPV plasma levels and the virological response.

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关键词

ABC,CDC,CYP450,HAART,HPLC,LPV,LPV/r,MDR,MRP,NNRTIs,NRTIs,PBMCs,PCR,P-gp,PI,PXR,RFLP,RTV,SNPs

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