Selenium-binding protein 1: its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Sayuri Tsujimoto,Takumi Ishida,Tomoki Takeda,Yuji Ishii,Yuko Onomura,Kiyomi Tsukimori,Shinji Takechi,Tadatoshi Yamaguchi,Hiroshi Uchi,Satoshi O Suzuki,Midori Yamamoto,Masaru Himeno,Masutaka Furue,Hideyuki Yamada

Biochimica et Biophysica Acta (BBA) - General Subjects（2013）

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摘要

•We generated Se-binding protein 1-null mice for clarifying its physiological role.•The null mice obtained exhibited little change in their apparent phenotypes.•However, the expression of many cancer-related genes in the ovary was changed.•Wasting syndrome caused by dioxin occurred equally both in KO and wild-type mice.

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关键词

AhR,ALT,AST,bp,Cyp,GPx,RT-PCR,Selenbp,TCDD,TBARS

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