Toxicity of thienopyridines on human neutrophil granulocytes and lymphocytes.

Swarna Maseneni,Massimiliano Donzelli,Karin Brecht,Stephan Krähenbühl

Toxicology（2013）

引用 16|浏览4

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摘要

•All thienopyridines studied were toxic for neutrophil granulocytes and lymphocytes.•Toxicity occurred at lower concentrations in granulocytes than in lymphocytes.•Susceptibility of granulocytes was due to metabolites formed by myeloperoxidase.•Metabolites and parent compounds induced apoptosis by a mitochondrial mechanism.

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关键词

Ticlopidine,Clopidogrel,Clopidogrel carboxylate,Prasugrel,Myelotoxicity,Granulocytes,Lymphocytes

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