The role of apoptosis in preterm premature rupture of the human fetal membranes
Archives of gynecology and obstetrics(2013)
摘要
Purpose The present study was designed to examine apoptotic cell death via the caspase-dependent pathway in human fetal membranes. Methods Amniotic membrane samples were collected from three groups of women: group 1, women with preterm premature rupture of fetal membranes (PPROM) after cesarean delivery ( n = 10), group 2, women with preterm labor (PTL) with intact membranes after cesarean delivery ( n = 9) and group 3, women with term labor and vaginal delivery after an uncomplicated pregnancy (controls) ( n = 11). Results Active caspase-3 immunopositivity (ACPI) of the PPROM group was significantly higher than that of the control group ( p < 0.05). ACPI was higher in the PTL with intact membranes group as compared to the control group; however, it did not reach statistical significance ( p > 0.05). Conclusion Active caspase-3 positivity is increased in the fetal membranes of those women with PPROM.
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关键词
Apoptosis,Caspase-3,Preterm premature rupture of membranes,Preterm labor
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