Mechanism of experimental autoimmune neuritis in Lewis rats: the dual role of macrophages.
HISTOLOGY AND HISTOPATHOLOGY(2013)
摘要
Human peripheral demyelinating diseases, such as Guillain-Barre syndrome (GBS), are characterized by inflammation and demyelination in the peripheral nervous system. Similarities in the pathology between GBS and the animal model of experimental autoimmune neuritis (EAN) indicate that autoimmune responses are involved in both diseases. This article summarizes the general aspects of the EAN model in Lewis rats and discusses the potential role of macrophages in the progression of EAN. A better understanding of macrophages may help to design alternative therapeutic strategies for organ-specific autoimmune diseases, including GBS.
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关键词
Alternatively activated macrophages,Experimental autoimmune neuritis,Guillain-Barre syndrome,Peripheral nervous system inflammation
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