Stereocontrolled synthesis of trichodermatide A.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2013)
Abstract
Hard core made easy: The pentacyclic core of trichodermatide A was stereoselectively synthesized from a bis(1,3-cyclohexanedione) derivative by a ring-closing reaction followed by an intramolecular ketal formation (see scheme; PPTS=pyridinium p-toluenesulfonate). The first total synthesis of trichodermatide A was then completed by the introduction of three hydroxy groups.
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Key words
cobalt,diastereoselective protection,natural products,polyketides,total synthesis
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