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Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature.

B Klump,O Nehls,T Okech,C-J Hsieh,V Gaco, F S Gittinger,M Sarbia,F Borchard,A Greschniok,H H Gruenagel,R Porschen,M Gregor

International journal of colorectal disease（2004）

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Abstract
Considering also our own findings, this review presents the latest developments in the scientific discussion of the tumor suppressor/oncogenes p53, k-ras, and DCC, biochemical determinants of the 5-fluorouracil metabolism, and defects of the DNA repair system.
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