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Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA

Benjamin Herquel,Khalid Ouararhni,Igor Martianov,Stéphanie Le Gras,Tao Ye,Céline Keime,Thierry Lerouge,Bernard Jost,Florence Cammas,Régine Losson,Irwin Davidson

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2013）

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Abstract
Trim24 and Trim33 are co-repressor complexes that suppress hepatocarcinogenesis. A new study now uncovers a function for Trim24 and Trim33 as repressors of VL30-type endogenous retroviruses in the liver. When derepressed, VL30 long terminal repeats (LTRs) function as promoter and enhancer elements deregulating expression of neighboring genes and generating noncoding enhancer RNAs that are required for LTR enhancer activity in hepatocytes.
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nature structural and molecular biology, science
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